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Psychiatry Pharmacogenomic (PGx) Panel
Psychiatry Pharmacogenomic (PGx) Panel

Psychiatry Pharmacogenomic (PGx) Panel

Turnaround Time: 10–14 days
Genes:COMT, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6.

Overview

Our Psychiatry Pharmacogenomic (PGx) Panel focuses on genetic variants with strong clinical evidence for their role in the metabolism, transport, and response to psychiatric medications, including antidepressants, antipsychotics and anxiolytics. This panel provides a detailed genetic profile to help guide safe, effective, and personalized mental health treatment strategies.

By identifying gene–drug interactions specific to psychiatric therapy, this test supports more precise prescribing—helping to reduce adverse effects, improve medication tolerability, and increase the likelihood of achieving symptom relief.

$199.00

What’s in Your Kit

  • 1 sterile cheek swabs
  • Secure collection tube
  • Detailed step-by-step instructions
  • Prepaid return shipping envelope
  • Patient consent form
  • Patient requsition form
  • Biohazard bag

Collection Instructions

Simple cheek swab (non-invasive, no needles required)

Avoid eating, drinking, smoking, or chewing gum for 30 minutes before collection

Pharmacogenics Specimen Collection Device

Let patient rinse mouth with clean water prior to the sample collection. Ensure patient does NOT eat, drink, smokeor chew tobacco, and chem gum for 30 minutes before collection specimen.

Label the outside of collection device patient’s Full Name, DOB, Date of Collection.

Open package and remove dry swab without touching sponge tip.

Place sponge tip as far back in the mouth and press firmly along the lower gums going up and down motion( against the inside of one cheek) . Use astopwatch to time the collection for at least 60 seconds per swab to collect cells. It is important to collect samples from maximum mucosal surfaces. If possible, avoid rubbing teeth.

Gently repeat step 4 on the opposite side of the cheek along the lower gums for additional 60 seconds.

Remove the swab from patient mouth and return the swab to the original specimen collection device containerand close the lid tightly.

Sample Final Report

  • Gene-by-gene analysis
  • Actionable recommendations for your provider
  • Medication list sorted by “Use as Directed,” “Use with Caution,” or “Consider Alternatives”
  • Educational notes for patients
  • Your response to hundreds of prescription medications
  • Individualized medication dosing guidelines
  • Personalized gene drug interactions

Medications and disease categories Covered

This panel evaluates genetic impact on over 80 psychiatric medications, including:
  • Antidepressants: SSRIs (fluoxetine, sertraline, citalopram, escitalopram, paroxetine), SNRIs (duloxetine, venlafaxine, desvenlafaxine), tricyclic antidepressants (amitriptyline, nortriptyline, imipramine), bupropion, mirtazapine
  • Antipsychotics: aripiprazole, risperidone, quetiapine, olanzapine, clozapine, haloperidol, ziprasidone
  • Anxiolytics and sedatives: buspirone, benzodiazepines, hypnotics
  • ADHD medications: atomoxetine, guanfacine, clonidine

Benefits Of Testing

  • Personalized psychiatric care – Matches medication selection and dosage to your genetic profile

  • Reduce trial-and-error prescribing – Minimizes the time spent finding the right medication

  • Reduce trial-and-error prescribing – Minimizes the time spent finding the right medication

  • Lifetime relevance – Results remain valid and can be used for future psychiatric treatment planning

  • Better treatment adherence – By improving tolerability and efficacy, patients are more likely to continue therapy

  • Optimized dosing – Assists in determining appropriate starting doses and adjustments for psychiatric drugs

Texas Diagnostics laboratories Medication Directory Filter through the list of medications and find yours
Category Therapeutic Class Generic Name Trade Name(s) Gene Evidence level
Psychotropic Anti-ADHD Agents Amphetamine Adderall, Evekeo COMT Informative
Psychotropic Anti-ADHD Agents Dexmethylphenidate Focalin COMT Informative
Psychotropic Anti-ADHD Agents Dextroamphetamine Dexedrine COMT Informative
Psychotropic Anti-ADHD Agents Lisdexamfetamine Vyvanse COMT Informative
Psychotropic Anti-ADHD Agents Methylphenidate Ritalin, Aptensio XR, Concerta, Metadate ER, Quillivant ER COMT Informative
Psychotropic Antipsychotics Clozapine Clozaril CYP1A2 Informative
Psychotropic Antipsychotics Olanzapine Zyprexa CYP1A2 Informative
Psychotropic Antiaddictives Bupropion Wellbutrin, Zyban, Aplenzin, Contrave CYP2B6 Informative
Psychotropic Antidepressants Sertraline Zoloft CYP2B6 Actionable
Psychotropic Antidepressants Amitriptyline Elavil CYP2C19 Actionable
Psychotropic Anticonvulsants Brivaracetam Briviact CYP2C19 Actionable
Psychotropic Antidepressants Citalopram Celexa CYP2C19 Actionable
Psychotropic Benzodiazepines Clobazam Onfi CYP2C19 Actionable
Psychotropic Antidepressants Clomipramine Anafranil CYP2C19 Actionable
Psychotropic Benzodiazepines Diazepam Valium CYP2C19 Informative
Psychotropic Antidepressants Doxepin Silenor CYP2C19 Actionable
Psychotropic Antidepressants Escitalopram Lexapro CYP2C19 Actionable
Psychotropic Other Neurological Agents Flibanserin Addyi CYP2C19 Actionable
Psychotropic Antidepressants Imipramine Tofranil CYP2C19 Actionable
Psychotropic Anticonvulsants Phenobarbital Luminal CYP2C19 Informative
Psychotropic Anticonvulsants Primidone Mysoline CYP2C19 Informative
Psychotropic Antidepressants Sertraline Zoloft CYP2C19 Actionable
Psychotropic Antidepressants Trimipramine Surmontil CYP2C19 Actionable
Psychotropic Anticonvulsants Zonisamide Zonegran CYP2C19 Informative
Psychotropic Anticonvulsants Fosphenytoin Cerebyx CYP2C9 Actionable
Psychotropic Anticonvulsants Phenytoin Dilantin CYP2C9 Actionable
Psychotropic Antipsychotics {Zuclopenthixol}^^ Clopixol CYP2D6 Actionable
Psychotropic Antidepressants Amitriptyline Elavil CYP2D6 Actionable
Psychotropic Antidepressants Amoxapine Amoxapine CYP2D6 Informative
Psychotropic Anti-ADHD Agents Amphetamine Adderall, Evekeo CYP2D6 Informative
Psychotropic Antipsychotics Aripiprazole Abilify, Aristada CYP2D6 Actionable
Psychotropic Anti-ADHD Agents Atomoxetine Strattera CYP2D6 Actionable
Psychotropic Antipsychotics Brexpiprazole Rexulti CYP2D6 Actionable
Psychotropic Antipsychotics Chlorpromazine Thorazine CYP2D6 Informative
Psychotropic Antidepressants Clomipramine Anafranil CYP2D6 Actionable
Psychotropic Antipsychotics Clozapine Clozaril CYP2D6 Actionable
Psychotropic Antidepressants Desipramine Norpramin CYP2D6 Actionable
Psychotropic Antidepressants Desvenlafaxine Pristiq CYP2D6 Actionable
Psychotropic Other Neurological Agents Deutetrabenazine Austedo CYP2D6 Actionable
Psychotropic Anti-ADHD Agents Dextroamphetamine Dexedrine CYP2D6 Informative
Psychotropic Other Neurological Agents Dextromethorphan / Quinidine Nuedexta CYP2D6 Actionable
Psychotropic Antidementia Agents Donepezil Aricept CYP2D6 Informative
Psychotropic Antidepressants Doxepin Silenor CYP2D6 Actionable
Psychotropic Antidepressants Fluoxetine Prozac, Sarafem CYP2D6 Informative
Psychotropic Antidepressants Fluvoxamine Luvox CYP2D6 Actionable
Psychotropic Antidementia Agents Galantamine Razadyne CYP2D6 Informative
Psychotropic Antipsychotics Haloperidol Haldol CYP2D6 Actionable
Psychotropic Antipsychotics Iloperidone Fanapt CYP2D6 Actionable
Psychotropic Antidepressants Imipramine Tofranil CYP2D6 Actionable
Psychotropic Anti-ADHD Agents Lisdexamfetamine Vyvanse CYP2D6 Informative
Psychotropic Antiaddictives Lofexidine Lucemyra CYP2D6 Actionable
Psychotropic Antidepressants Maprotiline Ludiomil CYP2D6 Informative
Psychotropic Antidepressants Nefazodone Serzone CYP2D6 Informative
Psychotropic Antidepressants Nortriptyline Pamelor CYP2D6 Actionable
Psychotropic Antipsychotics Paliperidone Invega CYP2D6 Actionable
Psychotropic Antidepressants Paroxetine Paxil, Brisdelle CYP2D6 Actionable
Psychotropic Antipsychotics Perphenazine Trilafon CYP2D6 Actionable
Psychotropic Antipsychotics Pimozide Orap CYP2D6 Actionable
Psychotropic Antidepressants Protriptyline Vivactil CYP2D6 Informative
Psychotropic Antipsychotics Risperidone Risperdal CYP2D6 Actionable
Psychotropic Other Neurological Agents Tetrabenazine Xenazine CYP2D6 Actionable
Psychotropic Antipsychotics Thioridazine Mellaril CYP2D6 Actionable
Psychotropic Antidepressants Trimipramine Surmontil CYP2D6 Actionable
Psychotropic Other Neurological Agents Valbenazine Ingrezza CYP2D6 Actionable
Psychotropic Antidepressants Venlafaxine Effexor CYP2D6 Actionable
Psychotropic Antidepressants Vortioxetine Trintellix CYP2D6 Actionable
Psychotropic Antiaddictives Naltrexone Vivitrol, Contrave OPRM1 Informative
Psychotropic Antiaddictives Bupropion Wellbutrin, Zyban, Aplenzin, Contrave ANKK1/DRD2 Informative
Psychotropic Benzodiazepines Lorazepam Ativan UGT2B15 Informative
Psychotropic Benzodiazepines Oxazepam Serax UGT2B15 Informative
Pyschotropic Anti-ADHD Agents Viloxazine Qelbree CYP2D6 Actionable
    Limitations
  • Detects only the targeted variants included in the panel; rare or novel variants are not identified.
  • Psychiatric treatment outcomes are influenced by non-genetic factors such as environment, stress, concurrent illness, and medication adherence.
  • A “normal metabolizer” result does not guarantee efficacy or absence of side effects.
  • Sample quality is essential; poor swab collection may result in incomplete or inconclusive results.
  • Pharmacogenomic interpretation may change as new research emerges.
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