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Comprehensive Pharmacogenomic (PGx) Panel
Comprehensive Pharmacogenomic (PGx) Panel

Comprehensive Pharmacogenomic (PGx) Panel

Turnaround Time: 10-14 days

Genes:  APOE, COMT, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, F2, F5, MTHFR, SLCO1B1, VKORC1.

Overview
Includes genes associated with drug metabolism with high-level evidence and clinically actionable guidelines. Our Comprehensive PGx Panel is designed to provide a complete genetic profile of how your body processes and responds to medications across multiple specialties, including cardiology, psychiatry, pain management, oncology, gastroenterology, gynecology, immunology, infectious disease, neurology, and more.
By identifying gene–drug interactions, this test helps your healthcare provider choose the right medication and dosage for you, reducing side effects and improving treatment success.

$299.00

What’s in Your Kit

  • 1 sterile cheek swabs
  • Secure collection tube
  • Detailed step-by-step instructions
  • Prepaid return shipping envelope
  • Patient consent form
  • Patient requsition form
  • Biohazard bag

Collection Instructions

Simple cheek swab (non-invasive, no needles required)

Avoid eating, drinking, smoking, or chewing gum for 30 minutes before collection

Pharmacogenics Specimen Collection Device

Let patient rinse mouth with clean water prior to the sample collection. Ensure patient does NOT eat, drink, smokeor chew tobacco, and chem gum for 30 minutes before collection specimen.

Label the outside of collection device patient’s Full Name, DOB, Date of Collection.

Open package and remove dry swab without touching sponge tip.

Place sponge tip as far back in the mouth and press firmly along the lower gums going up and down motion( against the inside of one cheek) . Use astopwatch to time the collection for at least 60 seconds per swab to collect cells. It is important to collect samples from maximum mucosal surfaces. If possible, avoid rubbing teeth.

Gently repeat step 4 on the opposite side of the cheek along the lower gums for additional 60 seconds.

Remove the swab from patient mouth and return the swab to the original specimen collection device containerand close the lid tightly.

Sample Final Report

  • Gene-by-gene analysis
  • Actionable recommendations for your provider
  • Medication list sorted by “Use as Directed,” “Use with Caution,” or “Consider Alternatives”
  • Educational notes for patients
  • Your response to hundreds of prescription medications
  • Individualized medication dosing guidelines
  • Personalized gene drug interactions

Medications and disease categories Covered

Over 159 medications across multiple therapeutic classes, including:
  • Cardiovascular: Blood thinners, statins, beta blockers, antiarrhythmics, cholesterol medications
  • Psychiatric: Antidepressants, antipsychotics, ADHD medications, mood stabilizers, selective serotonin reuptake inhibitors
  • Pain Management: Opioids, NSAIDs, muscle relaxants, Anti-inflammatory drugs
  • Oncology: Protein kinase inhibitors, hormone therapies, Chemotrapies, antinoeplastic agents
  • Gastrointestinal: Proton pump inhibitors, antiemetics, heartburn, gastroesophageal reflux disease treatment
  • Gynecology:  Female health medications
  • Immunology: Immunosuppressants
  • Infectious disease : Antibiotics, antifungals, antimalarials, antivirals — includes treatments for HIV
  • Neurology: Anticonvulsants, muscle relaxants, movement disorder treatments
  • Other: Antiviral agents, transplant medications, urological drugs, autoimmune treatments, anti-nausea, anti-emetics, Potassium channel blockers
(Full medication list available in “Detailed Medication Coverage” tab)

Benefits Of Testing

  • Personalized treatment – Tailors medication type and dosage to your genetic profile

  • Reduced trial-and-error prescribing – Helps avoid ineffective medications

  • Toxicity: Lower risk of adverse drug reactions – Minimizes harmful side effects

  • Lifetime value – Your genetic results never change and can be referenced for all future prescriptions. PGx test results become part of a patient’s medical record, allowing physicians to make more informed decisions when prescribing medications for future medical issues.

  • Applicable across multiple specialties – One test covers many healthcare needs

  • Lack of efficacy- The body cannot absorb enough of the drug to achieve a therapeutic effect.

  • Identify which drug may be most effective before treatment starts-PGx testing can help clinicians choose the most effective drug for each patient, minimize the risk of ADRs, and reduce hospitalizations.

  • Adjust and optimize the dose of current medications-PGx testing can help clinicians predict the appropriate dose of medication for their patient. This allows them to create more personalized medication plans to maximize efficacy and reduce pharmacy costs.

Texas Diagnostics laboratories Medication Directory Filter through the list of medications and find yours
Category Therapeutic Class Generic Name Trade Name(s) Gene Evidence level comprehensive panel
Anticancer Agents Protein Kinase Inhibitors Erdafitinib Balversa CYP2C9 Actionable Yes
Anticancer Agents Protein Kinase Inhibitors Gefitinib Iressa CYP2D6 Actionable Yes
Anticancer Agents Anti-Estrogens Tamoxifen Nolvadex, Soltamox CYP2D6 Actionable Yes
Anticancer Agents Antifolates Methotrexate Trexall MTHFR Informative Yes
Antihistamines Histamine (H1) Receptor Antagonists Meclizine Antivert CYP2D6 Actionable Yes
Cardiovascular x x x APOE Informative Yes
Cardiovascular Antiplatelets Clopidogrel Plavix CYP2C19 Actionable Yes
Cardiovascular Cardiac myosin inhibitor Mavacamten Camzyos CYP2C19 Actionable Yes
Cardiovascular Angiotensin II Receptor Antagonists Azilsartan Edarbi, Edarbyclor CYP2C9 Informative Yes
Cardiovascular Statins Fluvastatin Lescol CYP2C9 Informative Yes
Cardiovascular Angiotensin II Receptor Antagonists Irbesartan Avapro CYP2C9 Informative Yes
Cardiovascular Angiotensin II Receptor Antagonists Losartan Cozaar, Hyzaar CYP2C9 Informative Yes
Cardiovascular Diuretics Torsemide Demadex CYP2C9 Informative Yes
Cardiovascular Anticoagulants Warfarin Coumadin CYP2C9 Actionable Yes
Cardiovascular Beta Blockers Carvedilol Coreg, Coreg CR CYP2D6 Actionable Yes
Cardiovascular Antiarrhythmics Flecainide Tambocor CYP2D6 Actionable Yes
Cardiovascular Beta Blockers Metoprolol Lopressor CYP2D6 Actionable Yes
Cardiovascular Antiarrhythmics Mexiletine Mexitil CYP2D6 Actionable Yes
Cardiovascular Beta Blockers Nebivolol Bystolic CYP2D6 Actionable Yes
Cardiovascular Antiarrhythmics Propafenone Rythmol CYP2D6 Actionable Yes
Cardiovascular Beta Blockers Propranolol Inderal CYP2D6 Actionable Yes
Cardiovascular Antianginal Agents Ranolazine Ranexa CYP2D6 Actionable Yes
Cardiovascular Beta Blockers Timolol Blocadren CYP2D6 Informative Yes
Cardiovascular Statins Atorvastatin Lipitor CYP3A4 Informative Yes
Cardiovascular Statins Lovastatin Mevacor, Altoprev, Advicor CYP3A4 Informative Yes
Cardiovascular Statins Atorvastatin Lipitor SLCO1B1 Actionable Yes
Cardiovascular Statins Fluvastatin Lescol SLCO1B1 Informative Yes
Cardiovascular Statins Lovastatin Mevacor, Altoprev, Advicor SLCO1B1 Informative Yes
Cardiovascular Statins Pitavastatin Livalo SLCO1B1 Informative Yes
Cardiovascular Statins Pravastatin Pravachol SLCO1B1 Informative Yes
Cardiovascular Statins Rosuvastatin Crestor SLCO1B1 Informative Yes
Cardiovascular Statins Simvastatin Zocor SLCO1B1 Actionable Yes
Cardiovascular Anticoagulants Warfarin Coumadin VKORC1 Actionable Yes
Dermatology Protein kinase inhibitor Abrocitinib Cibinqo CYP2C19 Actionable Yes
Diabetes Meglitinides Nateglinide Starlix CYP2C9 Informative Yes
Diabetes Meglitinides Nateglinide Starlix SLCO1B1 Informative Yes
Diabetes Meglitinides Repaglinide Prandin, Prandimet SLCO1B1 Informative Yes
Gastrointestinal Proton Pump Inhibitors Dexlansoprazole Dexilant, Kapidex CYP2C19 Actionable Yes
Gastrointestinal Proton Pump Inhibitors Esomeprazole Nexium CYP2C19 Actionable Yes
Gastrointestinal Proton Pump Inhibitors Lansoprazole Prevacid CYP2C19 Actionable Yes
Gastrointestinal Proton Pump Inhibitors Omeprazole Prilosec CYP2C19 Actionable Yes
Gastrointestinal Proton Pump Inhibitors Pantoprazole Protonix CYP2C19 Actionable Yes
Gastrointestinal Proton Pump Inhibitors Rabeprazole Aciphex CYP2C19 Actionable Yes
Gastrointestinal Antiemetics Dronabinol Marinol CYP2C9 Actionable Yes
Gastrointestinal Antiemetics Dolasetron Anzemet CYP2D6 Informative Yes
Gastrointestinal Antiemetics Fosnetupitant / Palonosetron Akynzeo-IV (Injection) CYP2D6 Informative Yes
Gastrointestinal Antiemetics Metoclopramide Reglan CYP2D6 Actionable Yes
Gastrointestinal Antiemetics Netupitant / Palonosetron Akynzeo (Oral) CYP2D6 Informative Yes
Gastrointestinal Antiemetics Ondansetron Zofran, Zuplenz CYP2D6 Actionable Yes
Gastrointestinal Antiemetics Palonosetron Aloxi CYP2D6 Informative Yes
Gaucher Disease Endocrine-Metabolic Agents Eliglustat Cerdelga CYP2D6 Actionable Yes
Gynecology Endometriosis Pain Agents Elagolix Orilissa SLCO1B1 Actionable Yes
Hematology Hemostatic Agents Avatrombopag Doptelet F2 Actionable Yes
Hematology Hemostatic Agents Lusutrombopag Mulpleta F2 Actionable Yes
Hematology Hemostatic Agents Avatrombopag Doptelet F5 Actionable Yes
Hematology Hemostatic Agents Eltrombopag Promacta F5 Actionable Yes
Hematology Hemostatic Agents Lusutrombopag Mulpleta F5 Actionable Yes
Infections Anti-HIV Agents Efavirenz Sustiva CYP2B6 Actionable Yes
Infections Antifungals Voriconazole Vfend CYP2C19 Actionable Yes
Multiple Sclerosis Disease-Modifying Agents Siponimod Mayzent CYP2C9 Actionable Yes
Pain Opioids Morphine MS Contin COMT Informative Yes
Pain Muscle Relaxants Tizanidine Zanaflex CYP1A2 Informative Yes
Pain Opioids Methadone Dolophine CYP2B6 Informative Yes
Pain Muscle Relaxants Carisoprodol Soma CYP2C19 Informative Yes
Pain NSAIDs Celecoxib Celebrex CYP2C9 Actionable Yes
Pain NSAIDs Flurbiprofen Ansaid CYP2C9 Actionable Yes
Pain NSAIDs Ibuprofen Advil, Motrin CYP2C9 Actionable Yes
Pain NSAIDs Meloxicam Mobic CYP2C9 Actionable Yes
Pain NSAIDs Piroxicam Feldene CYP2C9 Actionable Yes
Pain Opioids Benzhydrocodone Apadaz CYP2D6 Actionable Yes
Pain Opioids Codeine Codeine; Fioricet with Codeine CYP2D6 Actionable Yes
Pain Opioids Dihydrocodeine Synalgos-DC CYP2D6 Informative Yes
Pain Opioids Hydrocodone Vicodin CYP2D6 Actionable Yes
Pain Opioids Oliceridine Olinvyk CYP2D6 Actionable Yes
Pain Opioids Oxycodone Percocet, Oxycontin CYP2D6 Actionable Yes
Pain Opioids Tramadol Ultram CYP2D6 Actionable Yes
Pain Opioids Fentanyl Actiq OPRM1 Informative NO-ADD ON
Pain Opioids Hydrocodone Vicodin OPRM1 Informative NO-ADD ON
Pain Opioids Morphine MS Contin OPRM1 Informative NO-ADD ON
Psychotropic Anti-ADHD Agents Amphetamine Adderall, Evekeo COMT Informative Yes
Psychotropic Anti-ADHD Agents Dexmethylphenidate Focalin COMT Informative Yes
Psychotropic Anti-ADHD Agents Dextroamphetamine Dexedrine COMT Informative Yes
Psychotropic Anti-ADHD Agents Lisdexamfetamine Vyvanse COMT Informative Yes
Psychotropic Anti-ADHD Agents Methylphenidate Ritalin, Aptensio XR, Concerta, Metadate ER, Quillivant ER COMT Informative Yes
Psychotropic Antipsychotics Clozapine Clozaril CYP1A2 Informative Yes
Psychotropic Antipsychotics Olanzapine Zyprexa CYP1A2 Informative Yes
Psychotropic Antiaddictives Bupropion Wellbutrin, Zyban, Aplenzin, Contrave CYP2B6 Informative Yes
Psychotropic Antidepressants Sertraline Zoloft CYP2B6 Actionable Yes
Psychotropic Antidepressants Amitriptyline Elavil CYP2C19 Actionable Yes
Psychotropic Anticonvulsants Brivaracetam Briviact CYP2C19 Actionable Yes
Psychotropic Antidepressants Citalopram Celexa CYP2C19 Actionable Yes
Psychotropic Benzodiazepines Clobazam Onfi CYP2C19 Actionable Yes
Psychotropic Antidepressants Clomipramine Anafranil CYP2C19 Actionable Yes
Psychotropic Benzodiazepines Diazepam Valium CYP2C19 Informative Yes
Psychotropic Antidepressants Doxepin Silenor CYP2C19 Actionable Yes
Psychotropic Antidepressants Escitalopram Lexapro CYP2C19 Actionable Yes
Psychotropic Other Neurological Agents Flibanserin Addyi CYP2C19 Actionable Yes
Psychotropic Antidepressants Imipramine Tofranil CYP2C19 Actionable Yes
Psychotropic Anticonvulsants Phenobarbital Luminal CYP2C19 Informative Yes
Psychotropic Anticonvulsants Primidone Mysoline CYP2C19 Informative Yes
Psychotropic Antidepressants Sertraline Zoloft CYP2C19 Actionable Yes
Psychotropic Antidepressants Trimipramine Surmontil CYP2C19 Actionable Yes
Psychotropic Anticonvulsants Zonisamide Zonegran CYP2C19 Informative Yes
Psychotropic Anticonvulsants Fosphenytoin Cerebyx CYP2C9 Actionable Yes
Psychotropic Anticonvulsants Phenytoin Dilantin CYP2C9 Actionable Yes
Psychotropic Antipsychotics {Zuclopenthixol}^^ Clopixol CYP2D6 Actionable Yes
Psychotropic Antidepressants Amitriptyline Elavil CYP2D6 Actionable Yes
Psychotropic Antidepressants Amoxapine Amoxapine CYP2D6 Informative Yes
Psychotropic Anti-ADHD Agents Amphetamine Adderall, Evekeo CYP2D6 Informative Yes
Psychotropic Antipsychotics Aripiprazole Abilify, Aristada CYP2D6 Actionable Yes
Psychotropic Anti-ADHD Agents Atomoxetine Strattera CYP2D6 Actionable Yes
Psychotropic Antipsychotics Brexpiprazole Rexulti CYP2D6 Actionable Yes
Psychotropic Antipsychotics Chlorpromazine Thorazine CYP2D6 Informative Yes
Psychotropic Antidepressants Clomipramine Anafranil CYP2D6 Actionable Yes
Psychotropic Antipsychotics Clozapine Clozaril CYP2D6 Actionable Yes
Psychotropic Antidepressants Desipramine Norpramin CYP2D6 Actionable Yes
Psychotropic Antidepressants Desvenlafaxine Pristiq CYP2D6 Actionable Yes
Psychotropic Other Neurological Agents Deutetrabenazine Austedo CYP2D6 Actionable Yes
Psychotropic Anti-ADHD Agents Dextroamphetamine Dexedrine CYP2D6 Informative Yes
Psychotropic Other Neurological Agents Dextromethorphan / Quinidine Nuedexta CYP2D6 Actionable Yes
Psychotropic Antidementia Agents Donepezil Aricept CYP2D6 Informative Yes
Psychotropic Antidepressants Doxepin Silenor CYP2D6 Actionable Yes
Psychotropic Antidepressants Fluoxetine Prozac, Sarafem CYP2D6 Informative Yes
Psychotropic Antidepressants Fluvoxamine Luvox CYP2D6 Actionable Yes
Psychotropic Antidementia Agents Galantamine Razadyne CYP2D6 Informative Yes
Psychotropic Antipsychotics Haloperidol Haldol CYP2D6 Actionable Yes
Psychotropic Antipsychotics Iloperidone Fanapt CYP2D6 Actionable Yes
Psychotropic Antidepressants Imipramine Tofranil CYP2D6 Actionable Yes
Psychotropic Anti-ADHD Agents Lisdexamfetamine Vyvanse CYP2D6 Informative Yes
Psychotropic Antiaddictives Lofexidine Lucemyra CYP2D6 Actionable Yes
Psychotropic Antidepressants Maprotiline Ludiomil CYP2D6 Informative Yes
Psychotropic Antidepressants Nefazodone Serzone CYP2D6 Informative Yes
Psychotropic Antidepressants Nortriptyline Pamelor CYP2D6 Actionable Yes
Psychotropic Antipsychotics Paliperidone Invega CYP2D6 Actionable Yes
Psychotropic Antidepressants Paroxetine Paxil, Brisdelle CYP2D6 Actionable Yes
Psychotropic Antipsychotics Perphenazine Trilafon CYP2D6 Actionable Yes
Psychotropic Antipsychotics Pimozide Orap CYP2D6 Actionable Yes
Psychotropic Antidepressants Protriptyline Vivactil CYP2D6 Informative Yes
Psychotropic Antipsychotics Risperidone Risperdal CYP2D6 Actionable Yes
Psychotropic Other Neurological Agents Tetrabenazine Xenazine CYP2D6 Actionable Yes
Psychotropic Antipsychotics Thioridazine Mellaril CYP2D6 Actionable Yes
Psychotropic Antidepressants Trimipramine Surmontil CYP2D6 Actionable Yes
Psychotropic Other Neurological Agents Valbenazine Ingrezza CYP2D6 Actionable Yes
Psychotropic Antidepressants Venlafaxine Effexor CYP2D6 Actionable Yes
Psychotropic Antidepressants Vortioxetine Trintellix CYP2D6 Actionable Yes
Psychotropic Antiaddictives Naltrexone Vivitrol, Contrave OPRM1 Informative NO-ADD ON
Psychotropic Antiaddictives Bupropion Wellbutrin, Zyban, Aplenzin, Contrave ANKK1/DRD2 Informative NO-ADD ON
Psychotropic Benzodiazepines Lorazepam Ativan UGT2B15 Informative NO-ADD ON
Psychotropic Benzodiazepines Oxazepam Serax UGT2B15 Informative NO-ADD ON
Pyschotropic Anti-ADHD Agents Viloxazine Qelbree CYP2D6 Actionable Yes
Rheumatology Immunomodulators Leflunomide Arava CYP2C19 Informative Yes
Sjogren’s Syndrome Cholinergic Agonists Cevimeline Evoxac CYP2D6 Actionable Yes
Sleep Disorder Agents Narcoleptic Agents Pitolisant Wakix CYP2D6 Actionable Yes
Transplantation Immunosuppressants Tacrolimus Prograf CYP3A5 Actionable Yes
Urologicals Antispasmodics for Overactive Bladder Darifenacin Enablex CYP2D6 Actionable Yes
Urologicals Antispasmodics for Overactive Bladder Fesoterodine Toviaz CYP2D6 Actionable Yes
Urologicals Antispasmodics for Overactive Bladder Mirabegron Myrbetriq CYP2D6 Actionable Yes
Urologicals Alpha-Blockers for Benign Prostatic Hypertrophy Tamsulosin Flomax CYP2D6 Actionable Yes
Urologicals Antispasmodics for Overactive Bladder Tolterodine Detrol CYP2D6 Actionable Yes
  Test Limitations:
  • Results do not imply that there are no other contributors, genetic or otherwise, to this individual’s phenotype, and  do not rule out a genetic cause for the indication for testing. Annotations for FDA, PharmGKB, and CPIC guidelines are updated regularly. Official gene names change over time. Result interpretation is based on the available clinical and family history information for this individual, collected published information, and Alamut annotation available at the time of reporting. This assay is designed and validated for detection of germline variants only. Analysis and reporting is limited to the diplotypes/markers explicitly listed on this report. This test cannot rule out the possibility that the tested individual has a rare or uncharacterized phenotype for genes on this panel.
  • Not a diagnostic test – It does not diagnose disease or predict all possible drug responses.
  • Variant coverage – Only the variants included on the panel will be reported; other genetic factors affecting drug response may not be assessed.
  • Non-genetic influences – Age, liver/kidney function, other medications, diet, and lifestyle can also affect drug metabolism and efficacy.
  • Ethnic variability – Test performance and interpretation may vary based on ancestry due to differences in variant prevalence.
  • Sample quality – Poor sample collection can lead to incomplete or inconclusive results.
  • Ongoing research – Pharmacogenomic science evolves; interpretation may change as new evidence emerges.
  • Targets are carefully selected based on established gene–drug interaction evidence from CPIC, PharmGKB, and FDA labeling.
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